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Though it is one of the most common causes of death in epilepsy patients, SUDEP is still infrequently and even reluctantly named on autopsy reports. This under-reporting equates to a lack of attention and earnest investigation into the cause, predisposition, and prevention of SUDEP. There is as yet little effort to establish an actionable strategy in the mitigation of these potentially fatal arrhythmias.
Expanding on the 1990 book Epilepsy and Sudden Death, edited by Lathers and Schraeder, Sudden Death in Epilepsy: Forensic and Clinical Issues reviews of the basic science of epilepsy as it relates to SUDEP. Clinical chapters study the sophisticated simultaneous ambulatory EKG and EEG telemetry and respiratory function monitoring of patients at risk for sudden death that will help identify cardiac, respiratory, and epileptogenic interactions involved. Chapters on animal models evaluate new data from studies that build on previously used models and emphasize that multiple models are needed to investigate the pathophysiology of SUDEP, to hypothesize about effective treatments, to develop pilot studies in persons with epilepsy, and to conduct confirmatory large-scale clinical trials.
Contributions discuss the interaction between the central and peripheral autonomic nervous systems and the cardiopulmonary systems; proposed mechanistic factors in SUDEP; risk categories of arrhythmogenic, respiratory, and hypoxia related cardiac death; psychological, emotional, and stress related factors; the role of alcohol and drugs in seizures; and the potential mitigating properties of antiepileptic medication.
Adopting a global, multidisciplinary focus to address the mystery of SUDEP, this important work provides clinicians, researchers, patients, and families with the knowledge to freely discuss the phenomenon and thereby discover the preventive treatment regimens to decrease the occurrence of SUDEP.
- Sales Rank: #2634668 in eBooks
- Published on: 2016-04-19
- Released on: 2016-04-19
- Format: Kindle eBook
Review
Lathers and colleagues have produced a colossal and astonishingly comprehensive tome on a little-appreciated subject: sudden death in epilepsy (SUDEP). All physicians who have treated patients with severe epilepsy have experienced the anguish of losing a young patient to this ill-defined syndrome. This book addresses all the issues--from the clinical to the basic, from the forensic to the bereavement. Every physician who treats epilepsy will do well to draw from the extraordinary compilation of data and expertise in this volume.
―Roger J. Porter, MD, ScD, Adjunct Professor of Neurology, University of Pennsylvania, Philadelphia and Adjunct Professor of Pharmacology, USUHS, Bethesda
The book is a skilled amalgam of neuroscience, cardiology, and pharmacology, along with numerous illustrative case examples, and it will become much thumbed-through as it takes a place of prominence on this forensic pathologist’s bookshelf.
―Gregory J. Davis, MD, FCAP, University of Kentucky College of Medicine, State Medical Examiner, Kentucky, in Et Cetera.
About the Author
Clinical Pharmacology Consultan, Albany, NY, USA Drexel University, Philadelphia, PA, USA University of Texas, Houston, TX, USA M.D., M.M. Chicago, Illinois, USA
Most helpful customer reviews
0 of 0 people found the following review helpful.
good but not well organized
By gamal osman
This book helped me on a paper i am working on right now. yet it needed to be more organized. There is no clear delineation between what the author mentions as forensic and clinical issues . for example risk factors are put under forensic issues. Afterall , i would recommend this book as it's the only recent book i know that thoroughly discussed this topic.
0 of 0 people found the following review helpful.
Excellent and comprehensive
By Marcus Gray
Very impressed by this textbook. Its scope is comprehensive and the content is accurate, detailed and up to date while including key findings over the past 40 years. I would highly recommend this textbook to researchers interested in Sudden Unexplained Death in Epilepsy.
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